Turner, Liliana F.

Person Preferred Name
Liliana F. Turner

Related Works

Default image for the object Nerve growth factor and striatal gluthathione metabolism in a rat model of Huntington's disease, object is lacking a thumbnail image
Nerve growth factor and striatal gluthathione metabolism in a rat model of Huntington's disease
Content type
Digital Document
Abstract
Examined the influence of nerve growth factor (NGF) on striatal glutathione (GSH) content and the activities of GSH-related enzymes from quinolinic acid (QA)-lesioned rats. 75 rats were intrastriatally injected with QA and NGF. Enzymatic and GSH assays were performed 1 week later. NGF prevented the QA-induced decline in glutathione reductase activity and GSH content. It is concluded that NGF is able to prevent some of the disturbances induced by the excitotoxic insult in the striatal GSH metabolism. <p> Purpose: To test the influence of nerve growth factor (NGF) on striatal glutathione (GSH) content and the activities of GSH-related enzymes from quinolinic acid-lesioned rats. <p>Methods: Rats were intrastriatally injected with QA and NGF. Enzymatic and GSH assays were performed one week later. <p>Results: NGF prevented the QA-induced decline in glutathione reductase activity and GSH content. <p>Conclusions: NGF is able to prevent some of the disturbances induced by the excitotoxic insult in the striatal GSH metabolism.
Origin Information
Subscribe to Turner, Liliana F.