Nerve growth factor and striatal gluthathione metabolism in a rat model of Huntington's disease
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Peer Review Status
Peer Reviewed
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Author (aut): Cruz-Aguado, Reyniel
Author (aut): Turner, Liliana F.
Author (aut): Dı́az, Carmen M.
Author (aut): Piñero, Janet
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| Abstract |
Abstract
Examined the influence of nerve growth factor (NGF) on striatal glutathione (GSH) content and the activities of GSH-related enzymes from quinolinic acid (QA)-lesioned rats. 75 rats were intrastriatally injected with QA and NGF. Enzymatic and GSH assays were performed 1 week later. NGF prevented the QA-induced decline in glutathione reductase activity and GSH content. It is concluded that NGF is able to prevent some of the disturbances induced by the excitotoxic insult in the striatal GSH metabolism.
Purpose: To test the influence of nerve growth factor (NGF) on striatal glutathione (GSH) content and the activities of GSH-related enzymes from quinolinic acid-lesioned rats. Methods: Rats were intrastriatally injected with QA and NGF. Enzymatic and GSH assays were performed one week later. Results: NGF prevented the QA-induced decline in glutathione reductase activity and GSH content. Conclusions: NGF is able to prevent some of the disturbances induced by the excitotoxic insult in the striatal GSH metabolism. |
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Volume 17, Issue 4
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ISSN
0922-6028
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| Use and Reproduction |
Use and Reproduction
©2001. Restorative Neurology and Neuroscience. IOS Press.
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Rights Statement
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| Keywords |
Keywords
nerve growth factor
striatum
Oxidative stress
Huntington's disease
quinolinic acid
glutathione
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