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- Title
- Diagnosis of hyperthyroidism in cats with mild chronic kidney disease
- Author(s)
- Jennifer Wakeling (author), K Moore (author), Jonathan Elliott (author), Harriet Syme (author)
- Date
- 2008
- Abstract
- Objectives: In cats with concurrent hyperthyroidism and non‐thyroidal illnesses such as chronic kidney disease, total thyroxine concentrations are often within the laboratory reference range (19 to 55 nmol/l). The objective of the study was to determine total thyroxine, free thyroxine and/or thyroid‐stimulating hormone concentrations in cats with mild chronic kidney disease. Methods: Total thyroxine, free thyroxine and thyroid‐stimulating hormone were measured in three groups. The hyperthyroidism‐chronic kidney disease group (n=16) had chronic kidney disease and clinical signs compatible with hyperthyroidism but a plasma total thyroxine concentration within the reference range. These cats were subsequently confirmed to be hyperthyroid at a later date. The chronic kidney disease‐only group (n=20) had chronic kidney disease but no signs of hyperthyroidism. The normal group (n=20) comprised clinically healthy senior (>8 years) cats. Results: In 4 of 20 euthyroid chronic kidney disease cats, free thyroxine concentrations were borderline or high (≥40 pmol/l). In the hyperthyroidism‐chronic kidney disease group, free thyroxine was high in 15 of 16 cats, while thyroid‐stimulating hormone was low in 16 of 16 cats. Most hyperthyroidism‐chronic kidney disease cats (14 of 16) had total thyroxine greater than 30 nmol/l, whereas all the chronic kidney disease‐only cats had total thyroxine less than 30 nmol/l. Clinical Significance: The combined measurement of free thyroxine with total thyroxine or thyroid‐stimulating hormone may be of merit in the diagnosis of hyperthyroidism in cats with chronic kidney disease.
- Subject(s)
- Cats--Diseases, Kidney diseases in animals, Hyperthyroidism--Diagnosis
- Department
- Veterinary Technology, Science and Technology
- Title
- Correlation of thyroid hormone measurements with thyroid stimulating hormone stimulation test results in radioiodine‐treated cats
- Author(s)
- Jennifer Wakeling (author), Teresa Hall (author), Timothy L. Williams (author)
- Date
- 2020
- Abstract
- [Background] Iatrogenic hypothyroidism can develop after radioiodine‐I131 (RAI) treatment of hyperthyroid cats and can be diagnosed using the thyroid stimulating hormone (TSH) stimulation test. [Objectives] To assess the effect of noncritical illness on TSH stimulation test results in euthyroid and RAI‐treated cats. To assess the correlation of low total‐thyroxine (tT4), low free‐thyroxine (fT4), and high TSH concentrations with TSH stimulation test results. [Animals] Thirty‐three euthyroid adult cats and 118 client‐owned cats previously treated with RAI. [Methods] Total‐thyroxine, fT4, and TSH were measured, and a TSH stimulation test was performed in all cats. Euthyroid control cats were divided into apparently healthy and noncritical illness groups. RAI‐treated cats were divided into RAI‐hypothyroid (after‐stimulation tT4 ≤ 1.5 μg/dL), RAI‐euthyroid (after‐stimulation tT4 ≥ 2.3 μg/dL OR after‐stimulation tT4 1.5‐2.3 μg/dL and before : after tT4 ratio > 1.5), and RAI‐equivocal (after stimulation tT4 1.5‐2.3 μg/dL and tT4 ratio < 1.5) groups. [Results] Noncritical illness did not significantly affect the tT4 following TSH stimulation in euthyroid (P = .38) or RAI‐treated cats (P = .54). There were 21 cats in the RAI‐equivocal group. Twenty‐two (85%) RAI‐hypothyroid cats (n = 26) and 10/71 (14%) of RAI‐euthyroid cats had high TSH (≥0.3 ng/mL). Twenty‐three (88%) RAI‐hypothyroid cats had low fT4 (<0.70 ng/dL). Of the 5 (7%) RAI‐euthyroid cats with low fT4, only one also had high TSH. Only 5/26 (19%) RAI‐hypothyroid cats had tT4 below the laboratory reference interval (<0.78 μg/dL). [Conclusions and Clinical Relevance] The veterinary‐specific chemiluminescent fT4 immunoassay and canine‐specific TSH immunoassay can be used to aid in the diagnosis of iatrogenic hypothyroidism in cats.
- Department
- Veterinary Technology, Science and Technology
- Title
- Proton, muon and 13C hyperfine coupling constants of C60X and C70X (X = H, Mu)
- Author(s)
- Jean Claude Brodovitch (author), Brenda Addison-Jones (author), Khashayar Ghandi (author), Iain McKenzie (author)
- Date
- 2015
- Abstract
- The reaction of H atoms with fullerene C70 has been investigated by identifying the radical products formed by addition of the atom muonium (Mu) to the fullerene in solution. Four of the five possible radical isomers of C70Mu were detected by avoided level-crossing resonance (μLCR) spectroscopy, using a dilute solution of enriched 13C70 in decalin. DFT calculations were used to predict muon and 13C isotropic hyperfine constants as an aid to assigning the observed μLCR signals. Computational methods were benchmarked against previously published experimental data for 13C60Mu in solution. Analysis of the μLCR spectrum resulted in the first experimental determination of 13C hyperfine constants in either C70Mu or C70H. The large number of values confirms predictions that the four radical isomers have extended distributions of unpaired electron spin.
- Department
- Chemistry, Science and Technology
- Title
- Assessment of HPV 16 and HPV 18 antibody responses by pseudovirus neutralization, Merck cLIA and Merck total IgG LIA immunoassays in a reduced dosage quadrivalent HPV vaccine trial
- Author(s)
- Mel Krajden (author), Darrel Cook (author), Amanda Yu (author), Ron Chow (author), Qiang Su (author), Wendy Mei (author), Shelly McNeil (author), Deborah Money (author), Marc Dionne (author), Joel Palefsky (author), Karuna Karunakaran (author), Tobias Kollmann (author), Gina Ogilvie (author), Martin Petric (author), Simon Dobson (author)
- Date
- 2014
- Abstract
- We assessed HPV 16 and 18 antibody responses of female subjects enrolled in a 2- vs. 3-dose quadrivalent HPV (Q-HPV) vaccine trial (ClinicalTrials.gov NCT00501137) using the Merck competitive Luminex (cLIA) and total IgG Luminex (TIgG) immunoassays, and a pseudovirus neutralizing antibody (PsV NAb) assay. Subjects were enrolled in one of three groups: (1) 9–13 yr, 2 doses of Q-HPV at 0, 6 months (n = 259); (2) 9–13 yr, 3 doses at 0, 2, 6 months (n = 260); and (3) 16–26 yr, 3 doses at 0, 2, 6 months (n = 305). Sera were collected from all subjects at baseline, months 7 and 24, and from half the subjects at months 18 and 36. High correlation was observed between all three assays. At month 36, HPV 16 antibodies remained detectable in all subjects by all assays, whereas 86.4%, 99.6% and 100% of subjects respectively were HPV 18 cLIA, TIgG and PsV NAb (partial neutralization endpoint) seropositive. The proportion seropositive for HPV 18 by cLIA at 36 months was not significantly different for 2-dose girls vs. 3-dose adults (85.9% vs. 79.4%; p = 0.51), whereas the proportion for 3-dose girls was significantly higher than for 3-dose adults (95.3% vs. 79.4%; p < 0.01). The HPV 18 seropositive proportions by the TIgG and PsV NAb (partial neutralization endpoint) assays were the same for all subjects. High baseline HPV 16 and HPV 18 seropositivity was observed for the TIgG assay and it is unclear if all the detected TIgG antibodies are type-specific and/or neutralizing. For the PsV NAb assay, 90% and partial neutralization geometric mean titres were consistently 2–8-fold higher than for 100% neutralization, which enabled detection of HPV 18 NAb in subjects who lost detectable cLIA antibodies over time. We conclude that the PsV NAb assay is more sensitive than the cLIA, and likely more specific than the TIgG assay.
- Subject(s)
- Papillomavirus vaccines, Viral antibodies, Immunoglobulins, Drugs--Dose-response relationship
- Department
- Biology, Science and Technology
- Title
- Enolization of acetone in superheated water detected via radical formation
- Author(s)
- Khashayar Ghandi (author), Brenda Addison-Jones (author), Jean-Claude Brodovitch (author), Brett M. McCollum (author), Iain McKenzie (author), Paul W. Percival (author)
- Date
- 2003
- Abstract
- Muoniated free radicals have been detected in muon-irradiated aqueous solutions of acetone at high temperatures and pressures. At temperatures below 250 °C, the radical product is consistent with muonium addition to the keto form of acetone. However, at higher temperatures, a different radical was detected, which is attributed to muonium addition to the enol form. Muon hyperfine coupling constants have been determined for both radicals over a wide range of temperatures, significantly extending the range of conditions under which these radicals and the keto−enol equilibrium have been studied.
- Department
- Chemistry, Science and Technology
- Title
- Near-diffusion-controlled reactions of muonium in sub- and supercritical water
- Author(s)
- Khashayar Ghandi (author), Brenda Addison-Jones (author), Jean-Claude Brodovitch (author), Iain McKenzie (author), Paul W. Percival (author), Joachim Schüth (author)
- Date
- 2002
- Abstract
- Rate constants are reported for near-diffusion-controlled reactions of muonium in sub- and supercritical water. Specifically, the spin-exchange interaction of muonium with Ni2 + and the addition of muonium to hydroquinone were studied as a function of temperature and pressure over a wide range of conditions, from standard to over 400 °C and 400 bar (the critical point of water is at 374 °C, 220 bar). At elevated temperatures the rate constants were found to have values far below those predicted by Stokes–Einstein–Smoluchowski theory. Furthermore, the temperature variation of the isobaric rate constants has a maximum in the subcritical region. The pressure dependence of the rate constants increases with temperature, consistent with the increase in compressibility of the solvent; the effective activation volumes are negative. Various models are explored to interpret the temperature and density dependence of the kinetic data. It is concluded that a key factor in the drop of rate constants at high temperature is the cage effect, in particular the number of collisions between a pair of reactants over the duration of their encounter.
- Department
- Chemistry, Science and Technology
- Title
- Bioinformatic analysis of chlamydia trachomatis polymorphic membrane proteins PmpE, PmpF, PmpG and PmpH as potential vaccine antigens
- Author(s)
- Alexandra Nunes (author), João P. Gomes (author), Karuna P. Karunakaran (author), Robert C. Brunham (author)
- Date
- 2015
- Abstract
- Chlamydia trachomatis is the most important infectious cause of infertility in women with important implications in public health and for which a vaccine is urgently needed. Recent immunoproteomic vaccine studies found that four polymorphic membrane proteins (PmpE, PmpF, PmpG and PmpH) are immunodominant, recognized by various MHC class II haplotypes and protective in mouse models. In the present study, we aimed to evaluate genetic and protein features of Pmps (focusing on the N-terminal 600 amino acids where MHC class II epitopes were mapped) in order to understand antigen variation that may emerge following vaccine induced immune selection. We used several bioinformatics platforms to study: i) Pmps’ phylogeny and genetic polymorphism; ii) the location and distribution of protein features (GGA(I, L)/FxxN motifs and cysteine residues) that may impact pathogen-host interactions and protein conformation; and iii) the existence of phase variation mechanisms that may impact Pmps’ expression. We used a well-characterized collection of 53 fully-sequenced strains that represent the C. trachomatis serovars associated with the three disease groups: ocular (N=8), epithelial-genital (N=25) and lymphogranuloma venereum (LGV) (N=20). We observed that PmpF and PmpE are highly polymorphic between LGV and epithelial-genital strains, and also within populations of the latter. We also found heterogeneous representation among strains for GGA(I, L)/FxxN motifs and cysteine residues, suggesting possible alterations in adhesion properties, tissue specificity and immunogenicity. PmpG and, to a lesser extent, PmpH revealed low polymorphism and high conservation of protein features among the genital strains (including the LGV group). Uniquely among the four Pmps, pmpG has regulatory sequences suggestive of phase variation. In aggregate, the results suggest that PmpG may be the lead vaccine candidate because of sequence conservation but may need to be paired with another protective antigen (like PmpH) in order to prevent immune selection of phase variants.
- Subject(s)
- Chlamydia trachomatis, Vaccines, Membrane proteins, Antigens, Immunoinformatics
- Department
- Biology, Science and Technology
- Title
- New dimensions of sport in modern Europe: Perspectives from the ‘Long Twentieth Century’
- Author(s)
- Robert. J. Lake (editor), Heather Dichter (editor), Mark Dyreson (editor)
- Date
- 2021
- Abstract
- New Dimensions of Sport in Modern Europe offers new perspectives on European sport history in the 'long twentieth century' designed to challenge and deconstruct what might be considered 'traditional' or more familiar Euro-centric conceptions and geographies of sport and leisure - especially those deriving from the leading hotbeds of European sport history. This anthology adds to the growing corpus of explorations of sport and leisure in late-modern European history from a variety of countries: France, Spain, Finland, Hungary, Bulgaria, and Slovenia. With topics covering several different sports and ranging from sport during empire to mega-events, and sport literature to women's sport attire, the insights provided by this new body of research demonstrate a greater understanding of the connections between sport and society in Europe throughout the long twentieth century.
- Subject(s)
- Sports--Europe--History--20th century, Sports--Social aspects--Europe--History--20th century, Europe--Social life and customs--20th century
- Department
- Sport Science, Science and Technology
- Title
- A comparative study of anaesthetic agents on high voltage activated calcium channel currents in identified molluscan neurons
- Author(s)
- Terrence J. Morris (author), Philip M. Hopkins (author), William Winlow (author)
- Date
- 2021
- Abstract
- 1. Using the two electrode voltage clamp configuration, a high voltage activated whole-cell Ca2+ channel current (IBa) was recorded from a cluster of neurosecretory ‘Light Yellow’ Cells (LYC) in the right parietal ganglion of the pond snail Lymnaea stagnalis. 2. Recordings of IBa from LYCs show a reversible concentration-dependent depression of current amplitude in the presence of the volatile anaesthetics halothane, isoflurane and sevoflurane, or the non-volatile anaesthetic pentobarbitone at clinical concentrations. 3. In the presence of the anaesthetics investigated, IBa measured at the end of the depolarizing test pulse showed proportionally greater depression than that at measured peak amplitude, as well as significant decrease in the rate of activation or increase in inactivation or both. 4. Within the range of concentrations used, the concentration-response plots for all the anaesthetics investigated correlate strongly to straight line functions, with linear regression R2 values > 0.99 in all instances. 5. For volatile anaesthetics, the dose-response regression slopes for IBa increase in magnitude, in order of gradient: sevoflurane, isoflurane and halothane, a sequence which reflects their order of clinical potency in terms of MAC value."
- Subject(s)
- Anesthetics--Physiological effect, Calcium channels--Effect of drugs on, Lymnaeidae--Effect of drugs on, Cells--Effect of drugs on, Cells--Electric properties, Neuropharmacology
- Department
- Biology, Science and Technology
- Title
- Detection of muoniated organic free radicals in supercritical water
- Author(s)
- Paul W Percival (author), Khashayar Ghandi (author), Jean-Claude Brodovitch (author), Brenda Addison-Jones (author), Iain McKenzie (author)
- Date
- 2000
- Abstract
- Muoniated free radicals have been detected in muon-irradiated aqueous solutions at high temperatures and pressures. Results are presented for the cyclohexadienyl radical, formed by muonium addition to benzene, and for tert-butyl, formed by reaction of muonium with isobutene, itself formed in situ from the dehydration of the starting material, tert-butanol. This is the first report of the direct identification of organic free radicals in near critical and supercritical water.
- Department
- Chemistry, Science and Technology
- Title
- Muonium in sub- and supercritical water
- Author(s)
- Paul W. Percival (author), Jean-Claude Brodovitch (author), Khashayar Ghandi (author), Brenda Addison-Jones (author), Joachim Schuth (author), David M. Bartels (author)
- Date
- 1999
- Abstract
- Muonium has been studied in muon-irradiated water over a wide range of conditions, from standard temperature and pressure (STP) up to 350 bar and up to 420[degree]C, corresponding to water densities from 1.0 down to 0.1 g cm. This is the first report of muonium in supercritical water. Muonium was unambiguously identified from its spin precession frequencies in small transverse magnetic fields. The hyperfine constant was determined and found to be similar to the published values for muonium in water at STP and in vacuum. Muonium was found to be long-lived over the whole range of conditions studied. The fraction of muons which form muonium was found to vary markedly over the density range studied. Correlation of the muonium fraction with the ionic product of water suggests a common cause, such as the rate of proton transfer between molecules involved in the radiolysis of water and the formation of MuOH, which competes with muonium formation.
- Department
- Chemistry, Science and Technology
- Title
- Open textbooks: We have led the horse to water – now what?
- Author(s)
- Jennifer Kirkey (author), Jennifer Barker (author)
- Date
- 2019
- Abstract
-
Poster presentation at the Canadian Association of Physicists conference at SFU, Burnaby (June 3-7, 2019).
The use of open textbooks is increasing dramatically in first year physics courses. This poster presents the results of scholarly research around student perceptions, the use and impact of open textbooks, as well as suggestions for how instructors might change what they do in their classroom around their use of open textbooks. Comparing and contrasting student’s attitudes in first year physics, astronomy and biology classes to open textbooks is the theme of this poster. It also relates attitudes towards open educational resources (OER) to simple demographic information and the overall cost of textbooks to determine whether there are indicators that can be measured a priori to suggest that students in a particular course may be more or less receptive to the incorporation of OER. More than 300 students were surveyed in 10 courses over two years at Douglas College so there is enough data to form interesting correlations. The questions that were asked included demographic questions as well as questions such as “How often does your instructor encourage you to read your textbook?” and “What is your best estimate of the percentage of exam questions that could be correctly answered using only the textbook?” Results: Student perceive that the open textbook is as good as or better than commercial books. Satisfaction increases as the book is modified to match learning outcomes.
- Subject(s)
- Postsecondary education, Open education, College textbooks, Physics--Textbooks
- Department
- Physics, Biology, Science and Technology
- Title
- Attending to multiple discrimination cues
- Author(s)
- Theodore Venema (author), Blas Espinoza-Varas (author)
- Date
- 1992
- Abstract
- Measures of listeners’ ability to attend to each of four possible discrimination cues were obtained. The stimuli comprised pairs (T1,T2) of 1500‐Hz, 80‐ms, 66‐dB SL tones separated by a 80‐ms silent interval [Espinoza‐Varas, J. Acoust. Soc. Am. 74, 1687–1694 (1983)]. In a three‐interval, 2AFC task, listeners discriminated a ‘‘standard’’ pair (interval 1) from a ‘‘comparison’’ pair (interval 2 or 3) containing increments in the duration (ΔT) or in the frequency (ΔF) of either T1 or T2. Each of the four possible increments was controlled by an adaptive track targeting 71‐percent‐correct thresholds (Levitt, 1971). Separate adaptive tracks were used for each increment, but all four tracks were interleaved randomly within a block of trials. That is, only one kind of increment occurred on a given trial, but all four increments alternated randomly within a block of trials. Each adaptive track terminated after 10 reversals, and thresholds were defined as the average increment value of the last five reversals. A block of trials terminated when the ten‐reversals criterion was reached with all four cues. The slope of the adaptive tracks and the thresholds reached after ten reversals provided measures of attention distribution. [Work supported by OCAST Grant No. HSO‐005 and Presbyterian Health Foundation.]
- Subject(s)
- Hearing, Hearing levels, Auditory perception--Testing, Audiometry
- Department
- Hearing Instrument, Science and Technology
- Title
- Compression for clinicians: A compass for hearing aid fittings
- Author(s)
- Theodore Venema (author)
- Date
- 2017
- Abstract
- Common clinical encounters: Do we really know them? -- The cochlea and outer hair cell damage -- Inner hair cell damage, traveling wave envelopes, and cochlear dead regions -- Early hearing aid fitting methods: Why so many? -- Verification with real ear measures: Yesterday and today -- Compression and the DSL and NAL fitting methods -- Compression in analog hearing aids: Historical development -- Compression and other features in digital hearing aids -- Clinical benefits of directional microphones versus digital noise reduction -- Adaptive dynamic range optimization: An alternative to WDRC. Third edition. From publisher description.
- Subject(s)
- Hearing aids--Fitting, Compression (Audiology), Hearing aids--Design and construction, Hearing aids, Cochlea--Physiology
- Department
- Hearing Instrument, Science and Technology
- Title
- Subclinical hyperthyroidism in cats: a spontaneous model of subclinical toxic nodular goiter in humans?
- Author(s)
- Jennifer Wakeling (author), Ken Smith (author), Tim Scase (author), Rachel Kirkby (author), Jonathan Elliott (author), Harriet Syme (author)
- Date
- 2007
- Abstract
- Introduction and Objectives: Hyperthyroidism in cats, caused by nodular hyperplasia or adenomas, is clinically and histologically similar to toxic nodular goiter in humans. Subclinical hyperthyroidism in humans is defined as low thyrotropin (TSH) in conjunction with within-reference-range thyroid hormone concentrations, but has not previously been defined in cats. The objective of this study was to test the hypothesis that euthyroid senior cats with low TSH have histological evidence of thyroid nodular hyperplasia and/or adenoma. Design: Thyroid glands removed postmortem from four groups of cats (n = 73) were examined histologically and scored in a blinded fashion. Clinically euthyroid senior (>7 years) cats were divided into two groups dependent on their TSH concentration—TSH below the limit of quantification (LOQ) of the assay (<0.03 ng/mL; n = 15; UndetectableTSH group) and TSH above the LOQ (≥0.03 ng/mL; n = 31; DetectableTSH group)—using archived plasma samples, collected 0–6 months antemortem. Thyroids were also scored for two control groups: Young group (cats <6 years old; n = 13) and Hyperthyroid group (clinically and biochemically hyperthyroid cats; n = 14). Main outcome: Cats in the UndetectableTSH group had a higher frequency of nodules, a greater percentage of abnormal thyroid tissue, and a higher overall histopathological grade than cats with detectable TSH had. Conclusion: Euthyroid (as defined by total thyroxine) senior cats with low TSH are likely to have histological evidence of nodular thyroid disease, and such cats could be considered to be subclinically hyperthyroid.
- Subject(s)
- Cats--Diseases, Hyperthyroidism, Hyperplasia, Goiter
- Department
- Veterinary Technology, Science and Technology
- Title
- Reflecting on good mathematics teaching: Knowing, nurturing, noticing
- Author(s)
- Susan Oesterle (author), Ann Kajander (editor), Jennifer Holm (editor), Egan J. Chernoff (editor)
- Date
- 2018
- Abstract
- The chapter "Reflecting on good mathematics teaching: Knowing, nurturing, noticing" was written by Susan Oesterle (Douglas College Faculty). The book brings together recent research and commentary in secondary school mathematics from a breadth of contemporary Canadian and International researchers and educators. It is both representative of mathematics education generally, as well as unique to the particular geography and culture of Canada. The chapters address topics of broad applicability such as technology in learning mathematics, recent interest in social justice contexts in the learning of mathematics, as well as Indigenous education. The voices of classroom practitioners, the group ultimately responsible for implementing this new vision of mathematics teaching and learning, are not forgotten. Each section includes a chapter written by a classroom teacher, making this volume unique in its approach. Part of the "Advances in mathematics education" series. Provided by publisher.
- Department
- Science and Technology
- Title
- Urinary iodide concentration in hyperthyroid cats
- Author(s)
- Jennifer Wakeling (author), Jonathan Elliott (author), Aviva Petrie (author), David Brodbelt (author), Harriet M. Syme (author)
- Date
- 2009
- Abstract
- Objective—To compare concentrations of urinary iodide (UI) in euthyroid and untreated hyperthyroid cats. Animals—118 euthyroid and 88 hyperthyroid client-owned cats from 2 nonreferral veterinary practices. Procedures—Iodide concentration was measured in 5 urine samples collected every 3 to 12 months from selected cats, and variability of results between euthyroid cats and hyperthyroid cats prior to the diagnosis of hyperthyroidism was evaluated via 1-way ANOVA, after logarithmic transformation of UI concentrations (logUIs). The UI concentration in hyperthyroid cats was measured at diagnosis and 2 to 6 weeks and 3 to 6 months after treatment for hyperthyroidism. The pretreatment logUI in hyperthyroid cats was compared with that in euthyroid cats, taking into account the effects of renal function on UI concentration. Iodine intake was estimated in euthyroid cats following calculation of the volume of daily urine output, with a fixed value for iodine concentration in feces. Results—The variability of UI concentrations did not differ significantly between hyperthyroid (n = 10) and euthyroid (8) cats. The logUI increased 2 to 6 weeks after initiation of treatment in hyperthyroid cats (n = 80) and was lower in azotemic versus nonazotemic cats. Hyperthyroid cats had a lower logUI than euthyroid cats, and there was no evidence of deficient iodine intake in euthyroid cats. Conclusions and Clinical Relevance—The logUI was lower in cats with azotemia and with untreated hyperthyroidism, compared with that in euthyroid cats from the same population. Additional studies are needed to determine whether iodine intake plays a role in the development of hyperthyroidism in cats.
- Subject(s)
- Cats--Diseases, Urine--Analysis, Iodine in the body, Iodine deficiency diseases, Hyperthyroidism
- Department
- Veterinary Technology, Science and Technology
- Title
- Muonium kinetics in sub- and supercritical water
- Author(s)
- Khashayar Ghandi (author), Brenda Addison-Jones (author), Jean-Claude Brodovitch (author), Iain McKenzie (author), Paul W. Percival (author)
- Date
- 2003
- Abstract
- Muonium is long-lived in pure water and has been studied over a very wide range of temperatures and pressures, from 5°C to over 400°C and from 1 to 400bar. We have determined rate constants for representative reactions of muonium in aqueous solution; equivalent data on H atom kinetics is sparse and stops well short of the maximum temperature and pressure attained in our experiments. The results show remarkable deviations from the predictions of standard reaction theories. In particular, rate constants pass through a maximum with temperature well below the critical point. This seems to be a general phenomenon, since we have observed it for spin-exchange and chemical reactions that are diffusion limited at low temperatures, as well as for activated reactions. We believe that a key factor in the drop of rate constants at high temperature is the cage effect, in particular the number of collisions between a pair of reactants over the duration of their encounter. Whatever the reason, the implications are profound for both the efficiency of supercritical water oxidation reactors and for the modelling of radiation chemistry in pressurized water nuclear reactors.
- Department
- Chemistry, Science and Technology
- Title
- ‘Success in Britain comes with an awful lot of small print’: Greg Rusedski and the precarious performance of national identity
- Author(s)
- Robert J. Lake (author), Jack Black (author), Thomas Fletcher (author)
- Date
- 2020
- Abstract
- Sport continues to be one of the primary means through which notions of Englishness and Britishness are constructed, contested, and resisted. The legacy of the role of sport in the colonial project of the British Empire, combined with more recent connections between sport and far right fascist/nationalist politics, has made the association between Britishness, Englishness, and ethnic identity(ies) particularly intriguing. In this paper, these intersections are explored through British media coverage of the Canadian-born, British tennis player, Greg Rusedski. This coverage is examined through the lens of ‘performativity,’ as articulated by Judith Butler. Through a critical application of Butler's ideas, the ways in which the media seek to recognise and normalise certain identities, while problematising and excluding others, can be more fully appreciated. Thus, it was within newspaper framings of Rusedski that hegemonic notions of White Englishness could be performed, maintained, and embedded.
- Subject(s)
- Sports--Great Britain--History, Sports--Social aspects--Great Britain, Sports--Political aspects--Great Britain, Nationalism and sports--Great Britain, Nationalism--Great Britain, National characteristics, British
- Department
- Sport Science, Science and Technology
- Title
- An unnerving otherness: English nationalism and Rusedski’s smile
- Author(s)
- Robert J. Lake (author), Jack Black (author), Thomas Fletcher (author)
- Date
- 2021
- Abstract
- In view of scholarly work that has explored the socio-psycho significance of national performativity, the body and the “other,” this article critically analyses newspaper representations of the Canadian-born British tennis player Greg Rusedski. Drawing on Lacanian interpretations of the body, it illustrates how Rusedski’s media framing centered on a particular feature of his body – his “smile.” In doing so, we detail how Rusedski’s “post-imperial” Otherness – conceived as a form of “extimacy” (extimité) – complicated any clear delineation between “us” and “them,” positing instead a dialectical understanding of the splits, voids and contradictions that underscore the national “us.”
- Subject(s)
- Sports--Social aspects--Great Britain, Nationalism and sports--Great Britain, Nationalism--Great Britain, Other (Philosophy)--Great Britain, Rusedski, Greg--Public opinion
- Department
- Sport Science, Science and Technology