Adaptation in membrane Ca2+ channels as a basis for alcohol-related pathology

Littleton, J.M.; Harper, J.C.; Brennan, C.H.; Guppy, Leon J.

doi:10.1080/09595238880000091

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Adaptation in membrane Ca2+ channels as a basis for alcohol-related pathology

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Littleton, J., Harper, J., Brennan, C., & Guppy, L. J. (1988). Adaptation in membrane Ca2+ channels as a basis for alcohol-related pathology. Australian Drug and Alcohol Review, 7(1), 35-38. https://doi.org/10.1080/09595238880000091

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Author(s): Littleton, J.M.
Harper, J.C.
Brennan, C.H.
Guppy, Leon J.
Title: Adaptation in membrane Ca2+ channels as a basis for alcohol-related pathology
Publication Type: article
Date: 1988
Journal/Book/Host Title: Australian Drug and Alcohol Review
Volume: 7
Issue: 1
Start Page: 35
End Page: 38
Abstract: This paper is a review, based largely though not exclusively on work from the authors' research group, of the role of Ca2+ channels in the actions of ethanol. The position is taken that an important consequence of the presence of ethanol in the region of excitable cells is a reduction in voltage-activation of membrane ion channels with a resulting decrease in cellular excitability. We suggest that excitable cells adapt to this effect by increasing the number of Ca2+ channels on the cell membrane. The channels are of a subtype which are inhibited by the dihydropyridine Ca2+ “antagonist” drugs. Although the mechanism of Ca2+ channel up-regulation is an effective short-term measure as adaptation against the acute effects of ethanol, we consider it may have detrimental longer term consequences including physical dependence and alcohol-related pathology including the death of excitable cells.
URI: https://www.tandfonline.com/doi/pdf/10.1080/09595238880000091?needAccess...
DOI: 10.1080/09595238880000091
ISSN: 0959-5236
Publication note: final article published
Author Keywords: Alcohol
ion channels
calcium channel blockers
alcoholism
ethyl-toxicity
Publisher: Taylor & Francis
Peer reviewed?: Peer reviewed